Civil Rights
Movements, leaders, victories and the continuing fight for equality.
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THE BHP WIRE —
HIDDEN TRUTHS
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Explore the people, places, events, achievements, struggles and stories that shaped our journey.
Movements, leaders, victories and the continuing fight for equality.
Innovation, patents, science, technology and world-changing contributions.
Pioneers, champions, Negro Leagues, records, activism and excellence.
Meet the people whose lives, choices and achievements shaped the journey.
Black towns, communities, institutions and places where history happened.
Moments that changed communities, movements, institutions and the nation.
Katherine Johnson’s mathematical calculations helped guide some of America’s most important early space missions while she confronted the racial and gender barriers faced by Black women in twentieth-century America.
MORE →Reflects the personal views, recollections, and perspective of the author, Mike Davis.
This is a personal recollection on the Move fire on May 13, 1985
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| Names | |
|---|---|
| Preferred IUPAC name
(2R)-2-Amino-5-phosphonopentanoic acid | |
| Identifiers | |
3D model (JSmol)
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| ChemSpider | |
| ECHA InfoCard | 100.150.904 |
PubChem CID
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| UNII | |
CompTox Dashboard (EPA)
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| Properties | |
| C5H12NO5P | |
| Molar mass | 197.13 g/mol |
| Appearance | white solid |
| Density | 1.529 g/mL |
| Boiling point | 482.1 °C (899.8 °F; 755.2 K) |
| Ammonium hydroxide, 50 mg/mL | |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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AP5 (also known as APV, (2R)-amino-5-phosphonovaleric acid, or (2R)-amino-5-phosphonopentanoate) is a chemical compound used as a biochemical tool to study various cellular processes. It is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors.[1] AP5 blocks NMDA receptors in micromolar concentrations (~50 μM).
AP5 blocks the cellular analog of classical conditioning in the sea slug Aplysia californica, and has similar effects on Aplysia long-term potentiation (LTP), since NMDA receptors are required for both.[2] It is sometimes used in conjunction with the calcium chelator BAPTA to determine whether NMDARs are required for a particular cellular process. AP5/APV has also been used to study NMDAR-dependent LTP in the mammalian hippocampus.[3]
In general, AP5 is very fast-acting within in vitro preparations, and can block NMDA receptor action at a reasonably small concentration. The active isomer of AP5 is considered to be the D configuration, although many preparations are available as a racemic mixture of D- and L-isomers. It is useful to isolate the action of other glutamate receptors in the brain, i.e., AMPA and kainate receptors.
AP5 can block the conversion of a silent synapse to an active one, since this conversion is NMDA receptor-dependent.
Source: Wikipedia. Article content is retrieved live through the MediaWiki API.
AP5 (also known as APV, (2R)-amino-5-phosphonovaleric acid, or (2R)-amino-5-phosphonopentanoate) is a chemical compound used as a biochemical tool to study various cellular processes. It is a selective NMDA receptor antagonist that competitively inhibits the ligand (glutamate) binding site of NMDA receptors. AP5 blocks NMDA receptors in micromolar concentrations (~50 μM). AP5 blocks the cellular analog of classical conditioning in the sea slug Aplysia californica, and has similar effects on Aplysia long-term potentiation (LTP), since NMDA receptors are required for both. It is sometimes used in conjunction with the calcium chelator BAPTA to determine whether NMDARs are required for a particular cellular process. AP5/APV has also been used to study NMDAR-dependent LTP in the mammalian hippocampus. In general, AP5 is very fast-acting within in vitro preparations, and can block NMDA receptor action at a reasonably small concentration. The active isomer of AP5 is considered to be the D configuration, although many preparations are available as a racemic mixture of D- and L-isomers. It is useful to isolate the action of other glutamate receptors in the brain, i.e., AMPA and kainate receptors. AP5 can block the conversion of a silent synapse to an active one, since this conversion is NMDA receptor-dependent.
The Chrysler AP5 Valiant is an automobile produced by Chrysler Australia from 1963 until 1965. It was the third Chrysler Valiant model to be produced in Australia.
USS Talladega (APA/LPA-208) was a Haskell-class attack transport of the US Navy. She was of the VC2-S-AP5 Victory ship design type. Talladega was named for Talladega County, Alabama.
Haskell-class attack transports (APAs) were amphibious assault ships of the United States Navy created in 1944. They were designed to transport 1,500 troops and their combat equipment and land them on hostile shores with the ships' integral landing craft. The Haskell ships were very active in the World War II Pacific Theater of Operations, landing marines and soldiers and transporting casualties at Iwo Jima and Okinawa. Ships of the class were among the first Allied ships to enter Tokyo Bay at the end of World War II, landing the first occupation troops at Yokosuka. After the end of World War II, most participated in Operation Magic Carpet, the massive sealift of US personnel back to the United States. A few of the Haskell class were reactivated for the Korean War, with some staying in service into the Vietnam War. The Haskell class, Maritime Commission standard type VC2-S-AP5, is a subtype of the World War II Victory ship design; 117 were launched in 1944 and 1945, with 14 more being finished as another VC2 type or canceled, built by the War Shipping Administration under the Emergency Shipbuilding program. The Haskell class was named for the so-named counties of Kansas, Oklahoma, and Texas.
Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.
MORE →Shirley Chisholm, elected in 1968.
