Civil Rights
Movements, leaders, victories and the continuing fight for equality.
q2K BHP
Black History Portal
THE BHP WIRE —
HIDDEN TRUTHS
What's New!
Explore the people, places, events, achievements, struggles and stories that shaped our journey.
Movements, leaders, victories and the continuing fight for equality.
Innovation, patents, science, technology and world-changing contributions.
Pioneers, champions, Negro Leagues, records, activism and excellence.
Meet the people whose lives, choices and achievements shaped the journey.
Black towns, communities, institutions and places where history happened.
Moments that changed communities, movements, institutions and the nation.
Katherine Johnson’s mathematical calculations helped guide some of America’s most important early space missions while she confronted the racial and gender barriers faced by Black women in twentieth-century America.
MORE →Reflects the personal views, recollections, and perspective of the author, Mike Davis.
This is a personal recollection on the Move fire on May 13, 1985
| KRT75 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Identifiers | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | KRT75, K6HF, KB18, PFB, keratin 75, CK-75, hK6hf, K75 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 609025; MGI: 1923500; GeneCards: KRT75 | |||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Wikidata | ||||||||||||||||||||||||||||||||||||||||||||||||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||
Keratin, type II cytoskeletal 75 is a protein that in humans is encoded by the KRT75 gene. It is a type of keratin involved in hair shaft structure in mice.[5] In chickens, mutations in KRT75 cause animals to have frizzled feathers.[6]
 | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information. |
Source: Wikipedia. Article content is retrieved live through the MediaWiki API.
Keratin, type II cytoskeletal 75 is a protein that in humans is encoded by the KRT75 gene. It is a type of keratin involved in hair shaft structure in mice. In chickens, mutations in KRT75 cause animals to have frizzled feathers.
Keratin () is one of a family of structural fibrous proteins also known as scleroproteins. It is the key structural material making up scales, hair, nails, feathers, horns, claws, hooves, and the outer layer of skin in tetrapod vertebrates. Keratin also protects epithelial cells from damage or stress. Keratin is extremely insoluble in water and organic solvents. Keratin monomers assemble into bundles to form intermediate filaments, which are tough and form strong unmineralized epidermal appendages found in reptiles, birds, amphibians, and mammals. Excessive keratinization participate in fortification of certain tissues such as in horns of cattle and rhinos, and armadillos' osteoderm. The only other biological matter known to approximate the toughness of keratinized tissue is chitin. Keratin comes in two types: the primitive, softer forms found in all vertebrates and the harder, derived forms found only among sauropsids (reptiles and birds).
Pleiotropy (from Ancient Greek πλείων (pleíōn) 'more' and τρόπος (trópos) 'turn, way, manner, style') is a condition in which a single gene or genetic variant influences multiple phenotypic traits. A gene that has such multiple effects is referred to as a pleiotropic gene. Mutations in pleiotropic genes can affect several traits simultaneously, often because the gene product is used in various cells and affects different biological targets through shared signaling pathways. Pleiotropy can result from several distinct but potentially overlapping mechanisms, including gene pleiotropy, developmental pleiotropy, and selectional pleiotropy. Gene pleiotropy occurs when a gene product interacts with multiple proteins or catalyzes different reactions. Developmental pleiotropy refers to mutations that produce several phenotypic effects during development. Selectional pleiotropy occurs when a single phenotype influences evolutionary fitness in multiple ways (depending on factors such as age and sex). There are also three main types of genetic pleiotropic effects when a variant or gene is associated with more than one trait: Biological pleiotropy, where a genetic variant directly affects multiple traits through biological pathways. Mediated pleiotropy, where a variant influences one trait, which in turn causes changes in a second trait, and Spurious pleiotropy, where statistical or methodological biases make it falsely appear as though a variant is associated with multiple traits. A well-known example of pleiotropy is phenylketonuria (PKU), a genetic disorder caused by a mutation in a single gene on chromosome 12 that encodes the enzyme phenylalanine hydroxylase. This mutation leads to the accumulation of the amino acid phenylalanine in the body, affecting multiple systems, such as the nervous and integumentary system. Pleiotropic gene action can limit the rate of multivariate evolution when natural selection, sexual selection or artificial selection on one trait favors one allele, while selection on other traits favors a different allele. Pleiotropic mutations can sometimes be deleterious, especially when they negatively affect essential traits. Genetic correlations and responses to selection most often exemplify pleiotropy. Pleiotropy is widespread in the genome, with many genes influencing biological traits and pathways. Understanding pleiotropy is crucial in genome-wide association studies (GWAS), where variants are often linked to multiple traits or diseases.
A frizzle refers to a plumage pattern in domesticated chickens (Gallus gallus domesticus) characterized by feathers that curl outwards, rather than lying flat as in most chickens. The frizzle type is not a separate breed, but a variety within breeds. Though all breeds of chickens may be frizzled; it is most commonly seen in breeds such as the Cochin, Pekin, and Polish. Chickens with this pattern are sometimes referred to as frizzles. The gene which causes the frizzles' peculiar feathering is an incomplete dominant trait.
Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.
MORE →Brown v. Board of Education in 1954.
