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MY'STORY

The MOVE Fire

This is a personal recollection on the Move fire on May 13, 1985 Philadelphia police fired thousands of rounds at the MOVE house, city officials approved dropping an explosive device on the roof, the resulting fire was allowed to burn, 11 people—including five children—died, and 61 homes were destroyed. Philadelphia City Council later called it a “brutal attack carried out by the City of Philadelphia on its own citizens” and acknowledged that no individual faced criminal consequences for the bombing. One timeline correction worth preserving for the BHP record: the major previous MOVE-police confrontation was August 8, 1978, about seven years before the bombing, not a year or two earlier. Officer James Ramp was killed, other police and firefighters were wounded, nine MOVE members were later convicted, and television cameras recorded police beating Delbert Africa during his arrest. The 1985 MOVE Commission later specifically criticized city planners for failing to adequately use lessons from that 1978 confrontation. And that actually strengthens the point you’re making: 1985 did not happen without precedent or institutional memory. There had already been a deadly confrontation with MOVE, years of conflict, negotiations and police involvement before Osage Avenue.

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BLACK FACTS
The Truths They Never Taught You...

Ruler of the Mali Empire in the 14th century

Mansa Musa was the ruler of the Mali Empire in West Africa. Details recorded here should be sourced; unknown information is left blank.

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BHP gathered finds from its connected research sources. Showing the 4 strongest Black History matches.
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Wikipedia

SL-75102

SL-75102
Names
IUPAC name
4-[[(4-Chlorophenyl)-(3-fluoro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]butanoic acid
Other names
Progabide acid; LS-187121; SL-75-102-00
Identifiers
3D model (JSmol)
ChEBI
ChEMBL
ChemSpider
UNII
  • InChI=1S/C17H15ClFNO3/c18-12-5-3-11(4-6-12)17(20-9-1-2-16(22)23)14-10-13(19)7-8-15(14)21/h3-8,10,21H,1-2,9H2,(H,22,23)/b20-17+
    Key: RRAXPPHKWFOGGL-LVZFUZTISA-N
  • c1cc(ccc1/C(=N\CCCC(=O)O)/c2cc(ccc2O)F)Cl
Properties
C17H15ClFNO3
Molar mass 335.76 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).

Progabide acid, also known as SL-75.102, is a GABA receptor agonist and an active metabolite of the anticonvulsant drug progabide.[1][2][3]

References

[edit]
  1. ^ Bergmann KJ (1985). "Progabide: a new GABA-mimetic agent in clinical use". Clin Neuropharmacol. 8 (1): 13–26. doi:10.1097/00002826-198503000-00002. PMID 2983890.
  2. ^ Hamberger, C.; Barre, J.; Brandebourger, M.; Urien, S.; Taiclet, A.; Thenot, J. P.; Tillement, J. P. (April 1987). "Progabide and SL 75102 binding to plasma proteins and red blood cells in humans". Int J Clin Pharmacol Ther Toxicol. 25 (4): 178–184. PMID 3583466.
  3. ^ Kubová, H.; Haugvicová, R.; Mares, P. (1997). "Anticonvulsant effect of SL 75 102 in adult and immature rats". Physiol Res. 46 (1): 73–76. PMID 9728525.


Source: Wikipedia. Article content is retrieved live through the MediaWiki API.

Wikipedia

Progabide

Progabide, sold under the brand name Gabrene, is a GABA receptor agonist which is used in the treatment of epilepsy. It is an analogue of γ-aminobutyric acid (GABA) and acts both via a metabolite and as a prodrug of GABA, in turn behaving as an agonist of the GABA receptors.

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Wikipedia

Tolgabide

Tolgabide (INN; development code SL-81.0142) is a drug which was patented by Synthélabo as an anticonvulsant but was never marketed. It is an analogue of progabide and acts similarly to it as a prodrug of GABA, and therefore as an indirect agonist of the GABA receptors.

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Wikipedia

SL-75102

Progabide acid, also known as SL-75.102, is a GABA receptor agonist and an active metabolite of the anticonvulsant drug progabide.

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Wikipedia

GABAA receptor agonist

A GABAA receptor agonist is a drug that acts as an orthosteric agonist of the GABAA receptor, the major signaling receptor of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The mechanism of action of GABAA receptor agonists is unlike that of GABAA positive allosteric modulators, including benzodiazepines, Z drugs, barbiturates, neurosteroids, and alcohol, which instead act via allosteric regulatory sites to potentiate GABAA receptor function. GABAA receptor agonists have different effects from those of GABAA receptor positive allosteric modulators. Examples of GABAA receptor agonists include GABA itself, γ-amino-β-hydroxybutyric acid (GABOB), muscimol (found in Amanita muscaria mushrooms), gaboxadol (THIP), and progabide, among others. High-efficacy GABAA receptor agonists have been found to produce sedative, hypnotic, anticonvulsant, and hallucinogenic effects, among others. The structural requirements for GABAA receptor binding and activation have been found to be very strict, so relatively few high-efficacy GABAA receptor agonists are known. No fully selective GABAA receptor agonists, for instance lacking any additional activity at the closely related GABAA-ρ and/or GABAB receptors, are currently known. GABAA receptor agonists are generally GABA analogues and derivatives. Muscimol, a conformationally restrained analogue of GABA, was among the first GABAA receptor agonists to be identified.

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TOPIC OF THE DAY

Greenwood / Black Wall Street

Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.

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TRIVIA QUESTION OF THE DAY

Which Supreme Court case ruled state-sponsored public-school segregation unconstitutional?

Brown v. Board of Education in 1954.