Civil Rights
Movements, leaders, victories and the continuing fight for equality.
Explore the people, places, events, achievements, struggles and stories that shaped our journey.
Movements, leaders, victories and the continuing fight for equality.
Innovation, patents, science, technology and world-changing contributions.
Pioneers, champions, Negro Leagues, records, activism and excellence.
Meet the people whose lives, choices and achievements shaped the journey.
Black towns, communities, institutions and places where history happened.
Moments that changed communities, movements, institutions and the nation.
Mansa Musa was the ruler of the Mali Empire in West Africa. Details recorded here should be sourced; unknown information is left blank.
MORE →Reflects the personal views, recollections, and perspective of the author, Mike Davis.
This is a personal recollection on the Move fire on May 13, 1985
Progabide, sold under the brand name Gabrene, is a GABA receptor agonist which is used in the treatment of epilepsy. It is an analogue of γ-aminobutyric acid (GABA) and acts both via a metabolite and as a prodrug of GABA, in turn behaving as an agonist of the GABA receptors.
Tolgabide (INN; development code SL-81.0142) is a drug which was patented by Synthélabo as an anticonvulsant but was never marketed. It is an analogue of progabide and acts similarly to it as a prodrug of GABA, and therefore as an indirect agonist of the GABA receptors.
Progabide acid, also known as SL-75.102, is a GABA receptor agonist and an active metabolite of the anticonvulsant drug progabide.
A GABAA receptor agonist is a drug that acts as an orthosteric agonist of the GABAA receptor, the major signaling receptor of the inhibitory neurotransmitter γ-aminobutyric acid (GABA). The mechanism of action of GABAA receptor agonists is unlike that of GABAA positive allosteric modulators, including benzodiazepines, Z drugs, barbiturates, neurosteroids, and alcohol, which instead act via allosteric regulatory sites to potentiate GABAA receptor function. GABAA receptor agonists have different effects from those of GABAA receptor positive allosteric modulators. Examples of GABAA receptor agonists include GABA itself, γ-amino-β-hydroxybutyric acid (GABOB), muscimol (found in Amanita muscaria mushrooms), gaboxadol (THIP), and progabide, among others. High-efficacy GABAA receptor agonists have been found to produce sedative, hypnotic, anticonvulsant, and hallucinogenic effects, among others. The structural requirements for GABAA receptor binding and activation have been found to be very strict, so relatively few high-efficacy GABAA receptor agonists are known. No fully selective GABAA receptor agonists, for instance lacking any additional activity at the closely related GABAA-ρ and/or GABAB receptors, are currently known. GABAA receptor agonists are generally GABA analogues and derivatives. Muscimol, a conformationally restrained analogue of GABA, was among the first GABAA receptor agonists to be identified.
Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.
MORE →Brown v. Board of Education in 1954.