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THE JOURNEY THROUGH TIME

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Explore the people, places, events, achievements, struggles and stories that shaped our journey.

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MY'STORY

The MOVE Fire

This is a personal recollection on the Move fire on May 13, 1985 Philadelphia police fired thousands of rounds at the MOVE house, city officials approved dropping an explosive device on the roof, the resulting fire was allowed to burn, 11 people—including five children—died, and 61 homes were destroyed. Philadelphia City Council later called it a “brutal attack carried out by the City of Philadelphia on its own citizens” and acknowledged that no individual faced criminal consequences for the bombing. One timeline correction worth preserving for the BHP record: the major previous MOVE-police confrontation was August 8, 1978, about seven years before the bombing, not a year or two earlier. Officer James Ramp was killed, other police and firefighters were wounded, nine MOVE members were later convicted, and television cameras recorded police beating Delbert Africa during his arrest. The 1985 MOVE Commission later specifically criticized city planners for failing to adequately use lessons from that 1978 confrontation. And that actually strengthens the point you’re making: 1985 did not happen without precedent or institutional memory. There had already been a deadly confrontation with MOVE, years of conflict, negotiations and police involvement before Osage Avenue.

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BLACK FACTS
The Truths They Never Taught You...

Katherine Johnson — Mathematics to the Moon

Katherine Johnson’s mathematical calculations helped guide some of America’s most important early space missions while she confronted the racial and gender barriers faced by Black women in twentieth-century America.

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BHP gathered finds from its connected research sources. Showing the 4 strongest Black History matches.
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Wikipedia

Retrogenix

Charles River High Peak
TypePublic
IndustryBiotechnology
FoundedSheffield, UK (2008)
FoundersDr. Jim Freeth, Jo Soden
ProductsHuman Cell Microarray Screening (Service)
Number of employees
11-50
Websitewww.criver.com [1]

Retrogenix is a biotechnology company based in the United Kingdom. Founded by Jim Freeth and Jo Soden in 2008, the company was acquired in April 2021 by Charles River Laboratories and is now known as the ‘High Peak’ site.

Research and development

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Currently, more than 4,500 proteins are simultaneously expressed in the Cell Microarray system for individual screening.[1] The human expression system allows for correct folding and localisation at the surface of the cell and there are documented cases of biological interactions that are mediated by post-translational modifications being detected using the technology.[2]

Applications in medical research

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The Cell Microarray technology identifies targets and receptors that are important in the understanding of normal biological and disease processes.[3] Diverse ligands can be screened using the technology which has led to the discovery of key receptors for malaria proteins[4] and targets that mediate virus binding to human cells.[5]

Target deconvolution

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Cell Microarray screening identifies the receptors for biologic molecules that have been selected through phenotypic screening. Notably, in studies led by Medimmune, the technology identified disease-relevant cell surface antigens of promising phenotypic molecules. [6]

Off-target profiling

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Cell Microarray off-target profiling assesses the specificity of ligands, either prior to clinical testing[7] or to uncover the mechanism of action for an observed adverse event or an unexpected pharmacokinetic profile.

Awards

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Retrogenix has twice won the Queen's Awards for Enterprise. The first award was granted for innovation in 2015.[8] This was followed by an award for international trade in 2017.[9]

References

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  1. ^ Freeth, J. "Target Practice". European Biopharmaceutical Review. No. Winter 2014. Samedan Ltd.
  2. ^ Salanti A, Clausen TM, Agerbæk M, Al Nakouzi N, Dahlbäck M, Oo HZ, Lee S, Gustavsson T, Rich JR, Hedberg BJ, Mao Y, Barington L, Pereira MA, LoBello J, Endo M, Fazli L, Soden J, Wang CK, Sander AF, Dagil R, Thrane S, Holst PJ, Meng L, Favero F, Weiss GJ, Nielsen MA, Freeth J, Nielsen TO, Zaia J, Tran NL, Trent J, Babcook JS, Theander TG, Sorensen PH, Daugaard M (2015). "Targeting human cancer by a glycosaminoglycan binding malaria protein". Cancer Cell. 28 (4): 500–514. doi:10.1016/j.ccell.2015.09.003. PMC 4790448. PMID 26461094.
  3. ^ "Removing the receptor deconvolution bottleneck". Genetic Engineering and Biotechnology News. Vol. 33, no. 14. August 2013.
  4. ^ Turner L, Lavstsen T, Berger SS, Wang CW, Petersen JE, Avril M, Brazier AJ, Freeth J, Jespersen JS, Nielsen MA, Magistrado P, Lusingu J, Smith JD, Higgins MK, Theander TG (2013). "Severe malaria is associated with parasite binding to endothelial protein C receptor". Nature. 498 (7455): 502–505. Bibcode:2013Natur.498..502T. doi:10.1038/nature12216. PMC 3870021. PMID 23739325.
  5. ^ Sosnovtsev SV, Sandoval-Jaime C, Parra GI, Tin CM, Jones RW, Soden J, Barnes D, Freeth J, Smith AW, Green KY (2017). "Identification of human junctional adhesion molecule-1 as a functional receptor for the Hom-1 calicivirus on humans cells". mBio. 8 (1). doi:10.1128/mBio.00031-17. PMC 5312078. PMID 28196955.
  6. ^ Sandercock AM, Rust S, Guillard S, Sachsenmeier KF, Holoweckyj N, Hay C, Flynn M, Huang Q, Yan K, Herpers B, Price LS, Soden J, Freeth J, Jermutus L, Hollingsworth R, Minter R (2015). "Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling". Molecular Cancer. 14: 147. doi:10.1186/s12943-015-0415-0. PMC 4521473. PMID 26227951.
  7. ^ Peng H, Nerreter T, Chang J, Qi J, Li X, Karunadharma P, Martinez G, Fallahi M, Soden J, Freeth J, Beerli RR, Grawunder U, Hudecek M & Rader C (2017). "Mining naïve rabbit antibody repertoires by phage display for monoclonal antibodies of therapeutic utility". Journal of Molecular Biology. 429 (19): 2954–2973. doi:10.1016/j.jmb.2017.08.003. PMC 5610937. PMID 28818634.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  8. ^ "Queen's Awards: Technical flair drives success in niche markets". Financial Times. 21 April 2015.
  9. ^ "Second Queen's award for High Peak business". Buxton Advertiser. 21 July 2017.
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Wikipedia

Retrogenix

Retrogenix is a biotechnology company based in the United Kingdom. Founded by Jim Freeth and Jo Soden in 2008, the company was acquired in April 2021 by Charles River Laboratories and is now known as the ‘High Peak’ site.

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Wikipedia

HCLTech

HCL Technologies Limited (HCLTech) is an Indian multinational technology company headquartered in Noida, Uttar Pradesh. It was spun out of HCL Group in 1991 when HCL entered into the software services business. Founded by Shiv Nadar, the company has presence in 60 countries and over 223,000 employees. It is the third-largest India-headquartered IT services company by revenue and market capitalization. The company unveiled its brand identity "HCLTech", underpinned by the distinct positioning of Supercharging Progress™, in 2022. HCLTech was named as the highest-ranked India-headquartered technology company for the second consecutive year in TIME magazine's World’s Best Companies list in 2025. It has also been included in TIME's World's Most Sustainable Companies list for the second consecutive year in 2026, placing it among the top five global professional companies. In 2026, HCLTech was named to Fortune magazine’s World’s Most Admired Companies list in the IT services category.

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Wikipedia

Charles River Laboratories

Charles River Laboratories International, Incorporated is an American life sciences company and contract research organisation (CRO) headquartered in Wilmington, Massachusetts, United States. Founded in 1947, the company provides goods and services that support the development of drugs, vaccines, and other therapeutics. Its operations span at least 20 countries, offering research models, drug discovery and safety assessment, and manufacturing and testing services to pharmaceutical, biotechnology, government, and other clients. Charles River Laboratories is a global provider of non-clinical drug development services, known for its role in toxicology studies, research animal models, and microbial testing services used in regulatory submissions to health authorities such as the U.S. Food and Drug Administration (FDA). The company has also been the subject of public scrutiny and regulatory attention over its use of research animals, including dogs, primates, and horseshoe crabs. As of 2024, the company employs over 20,000 people worldwide and is publicly traded on the New York Stock Exchange under the ticker symbol CRL.

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Wikipedia

Wipro

Wipro Limited ( ) is an Indian multinational technology company based in Bengaluru. It provides information technology, consulting and business process services, and is one of India's Big Six IT services companies. Wipro's services include cloud computing, computer security, digital transformation, artificial intelligence, robotics, data analytics, and other technologies.

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TOPIC OF THE DAY

Greenwood / Black Wall Street

Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.

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TRIVIA QUESTION OF THE DAY

Who was the first African-American woman millionaire in the United States?

Madam C.J. Walker