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MY'STORY

The MOVE Fire

This is a personal recollection on the Move fire on May 13, 1985 Philadelphia police fired thousands of rounds at the MOVE house, city officials approved dropping an explosive device on the roof, the resulting fire was allowed to burn, 11 people—including five children—died, and 61 homes were destroyed. Philadelphia City Council later called it a “brutal attack carried out by the City of Philadelphia on its own citizens” and acknowledged that no individual faced criminal consequences for the bombing. One timeline correction worth preserving for the BHP record: the major previous MOVE-police confrontation was August 8, 1978, about seven years before the bombing, not a year or two earlier. Officer James Ramp was killed, other police and firefighters were wounded, nine MOVE members were later convicted, and television cameras recorded police beating Delbert Africa during his arrest. The 1985 MOVE Commission later specifically criticized city planners for failing to adequately use lessons from that 1978 confrontation. And that actually strengthens the point you’re making: 1985 did not happen without precedent or institutional memory. There had already been a deadly confrontation with MOVE, years of conflict, negotiations and police involvement before Osage Avenue.

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BLACK FACTS
The Truths They Never Taught You...

Shirley Chisholm — Unbought and Unbossed

In 1968 Shirley Chisholm became the first Black woman elected to the United States Congress. In 1972 she launched a campaign for the Democratic presidential nomination, breaking another political barrier.

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Wikipedia

SLBP

SLBP
Identifiers
AliasesSLBP, HBP, stem-loop binding protein
External IDsOMIM: 602422; MGI: 108402; GeneCards: SLBP
Available structures
PDBOrtholog search: PDBe RCSB
Orthologs
DatabasesNCBI: entry; OMA: entry
SpeciesHumanMouse
Entrez

7884

20492

Ensembl

ENSG00000163950

ENSMUSG00000004642

UniProt

Q14493
Q53XR2

P97440

RefSeq (mRNA)

NM_001306074
NM_001306075
NM_006527

NM_001289724
NM_001289725
NM_009193

RefSeq (protein)

NP_001293003
NP_001293004
NP_006518
NP_006518.1

NP_001276653
NP_001276654
NP_033219

Location (UCSC)Chr 4: 1.69 – 1.71 MbChr 5: 33.79 – 33.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Histone RNA hairpin-binding protein or stem-loop binding protein (SLBP) is a protein that in humans is encoded by the SLBP gene.[5][6][7]

Species distribution

[edit]

SLBP has been cloned from humans, C. elegans, D. melanogaster, X. laevis, and sea urchins.[8] The full length human protein has 270 amino acids (31 kDa) with a centrally located RNA binding domain (RBD). The 75 amino acid RBD is well conserved across species, however the remainder of SLBP is highly divergent in most organisms and not homologous to any other protein in the eukaryotic genomes.

Function

[edit]

This gene encodes a protein that binds to the histone 3' UTR stem-loop structure in replication-dependent histone mRNAs. Histone mRNAs do not contain introns or polyadenylation signals, and are processed by a single endonucleolytic cleavage event downstream of the stem-loop. The stem-loop structure is essential for efficient processing of the histone pre-mRNA but this structure also controls the transport, translation and stability of histone mRNAs. SLBP expression is regulated during S-phase of the cell cycle, increasing more than 10-fold during the latter part of G1.

All SLBP proteins are capable of forming a highly stable complex with histone stem-loop RNA. Complex formation with the histone mRNA stem-loop is achieved by a novel three-helix bundle fold. SLBP proteins also recognize the tetraloop structure of the histone hairpin, the base of the stem, and the 5' flanking region. The crystal structure of human SLBP in complex with the stem-loop RNA as well as the exonuclease Eri1 reveals that the Arg181 residue of SLBP specifically interacts with the second guanine base in the RNA stem.[9] The rest of the protein is intrinsically disordered in fruit-flies as well as in humans. A unique feature of the SLBP RBD is that it is phosphorylated in its RNA binding domain at the Thr171 residue. The SLBP RBD also undergoes proline isomerization about this sequence and is a substrate for the prolyl isomerase Pin1. The N-terminal domain of human SLBP is required for translation activation of histone mRNAs via its interaction with SLIP1. SLBP also interacts with the CBP80 associated protein CTIF to facilitate rapid degradation of histone mRNAs. SLBP is a phosphoprotein and besides T171, it is also phosphorylated at Ser7, Ser20, Ser23, Thr60, Thr61 in mammalian cells. The phosphorylation at Thr60 is mediated by CK2 and Thr61 is by Cyclin A/Cdk1.[7]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163950 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004642 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Martin F, Schaller A, Eglite S, Schumperli D, Muller B (March 1997). "The gene for histone RNA hairpin binding protein is located on human chromosome 4 and encodes a novel type of RNA binding protein". The EMBO Journal. 16 (4): 769–778. doi:10.1093/emboj/16.4.769. PMC 1169678. PMID 9049306.
  6. ^ McCombie WR, Martin-Gallardo A, Gocayne JD, FitzGerald M, Dubnick M, Kelley JM, et al. (August 1992). "Expressed genes, Alu repeats and polymorphisms in cosmids sequenced from chromosome 4p16.3". Nature Genetics. 1 (5): 348–353. doi:10.1038/ng0892-348. PMID 1338771. S2CID 6716635.
  7. ^ a b "Entrez Gene: SLBP stem-loop (histone) binding protein".
  8. ^ Wang ZF, Whitfield ML, Ingledue TC, Dominski Z, Marzluff WF (December 1996). "The protein that binds the 3' end of histone mRNA: a novel RNA-binding protein required for histone pre-mRNA processing". Genes & Development. 10 (23): 3028–3040. doi:10.1101/gad.10.23.3028. PMID 8957003.
  9. ^ Tan D, Marzluff WF, Dominski Z, Tong L (January 2013). "Structure of histone mRNA stem-loop, human stem-loop binding protein, and 3'hExo ternary complex". Science. 339 (6117). New York, N.Y.: 318–321. doi:10.1126/science.1228705. PMC 3552377. PMID 23329046.

Further reading

[edit]

Source: Wikipedia. Article content is retrieved live through the MediaWiki API.

Wikipedia

SLBP

Histone RNA hairpin-binding protein or stem-loop binding protein (SLBP) is a protein that in humans is encoded by the SLBP gene.

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Wikipedia

Histone 3′ UTR stem-loop

The histone 3′ UTR stem-loop is an RNA element involved in nucleocytoplasmic transport of the histone mRNAs, and in the regulation of stability and of translation efficiency in the cytoplasm. The mRNAs of metazoan histone genes lack polyadenylation and a poly-A tail, instead 3′ end processing occurs at a site between this highly conserved stem-loop and a purine rich region around 20 nucleotides downstream (the histone downstream element, or HDE). The stem-loop is bound by a 31 kDa stem-loop binding protein (SLBP - also termed the histone hairpin binding protein, or HBP). Together with U7 snRNA binding of the HDE, SLBP binding nucleates the formation of the processing complex.

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Wikipedia

MIF4GD

MIF4GD, or MIF4G domain-containing protein, is a protein which in humans is encoded by the MIF4GD gene. It is also known as SLIP1, SLBP (Stem-Loop Binding Protein)-interacting protein 1, AD023, and MIFD. MIF4GD is expressed ubiquitously in humans, and has been found to be involved in activating proteins for histone mRNA translation, alternative splicing and translation of mRNAs, and is a factor in the regulation of cell proliferation.

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Wikipedia

International Capital Market Association

The International Capital Market Association (ICMA) is a not-for-profit global trade association, for participants in the cross-border debt capital markets, with offices in Zurich, London, Paris, Brussels and Hong Kong. ICMA provides industry-driven standards and recommendations. ICMA works with regulatory and governmental authorities, helping to ensure that financial regulation supports stable and efficient capital markets. Since 2014, ICMA has been providing the Secretariat for the Principles (the Green Bond Principles (GBP), the Social Bond Principles (SBP), the Sustainability Bond Guidelines (SBG) and the Sustainability-Linked Bond Principles (SLBP)) that underpin the global sustainable bond market. Since December 2022, ICMA has also been providing the Secretariat to the voluntary Code of Conduct for ESG Ratings and Data Providers. Originally established in Zurich under Swiss Law (Zurich) in February 1969 as the Association of International Bond Dealers (AIBD), the International Capital Market Association was formed in July 2005 from the merger of International Primary Market Association and the International Securities Market Association (formerly the AIBD) to create an association that covered both primary and secondary international capital markets.

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TOPIC OF THE DAY

Greenwood / Black Wall Street

Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.

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TRIVIA QUESTION OF THE DAY

Which Supreme Court case ruled state-sponsored public-school segregation unconstitutional?

Brown v. Board of Education in 1954.