Civil Rights
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Mansa Musa was the ruler of the Mali Empire in West Africa. Details recorded here should be sourced; unknown information is left blank.
MORE →Reflects the personal views, recollections, and perspective of the author, Mike Davis.
This is a personal recollection on the Move fire on May 13, 1985


Troponin C (TnC) is part of the troponin protein complex. There are two subtypes in humans:
It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.
TnC is structurally similar to calmodulin and myosin light chain. These three groups of proteins form a family.[1]
| Troponin C, slow skeletal and cardiac muscles | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TNNC1 | ||||||
| HGNC | 11943 | ||||||
| OMIM | 191040 | ||||||
| RefSeq | NM_003280 | ||||||
| UniProt | P63316 | ||||||
| Other data | |||||||
| Locus | Chr. 3 p21.1 | ||||||
| |||||||
| Troponin C, skeletal muscle | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | TNNC2 | ||||||
| HGNC | 11944 | ||||||
| OMIM | 191039 | ||||||
| RefSeq | NP_003270.1 | ||||||
| UniProt | P02585 | ||||||
| Other data | |||||||
| Locus | Chr. 20 q13.12 | ||||||
| |||||||
Source: Wikipedia. Article content is retrieved live through the MediaWiki API.
Troponin C (TnC) is part of the troponin protein complex. There are two subtypes in humans: Troponin C, slow skeletal and cardiac muscles (TNNC1) (3p21.1 Online Mendelian Inheritance in Man (OMIM): 191040) Troponin C, skeletal muscle (TNNC2) (20q12-q13.11, Online Mendelian Inheritance in Man (OMIM): 191039) It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding. TnC is structurally similar to calmodulin and myosin light chain. These three groups of proteins form a family.
Troponin C, slow skeletal and cardiac muscles (TN-C) is a protein encoded in the human by the TNNC1 gene. TN-C resides in the troponin complex on actin thin filaments of striated muscle (slow-twitch cardiac and skeletal) and is responsible for binding calcium to activate muscle contraction. It is one of the two troponin C paralogs in humans.
Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of calmodulin. Once bound to Ca2+, calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases.
Troponin, or the troponin complex, is a complex of three subunits of specialized regulatory proteins –troponin C, troponin I, and troponin T, that are components of the contraction mechanism in striated muscle. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocarditis, myocardial infarction and acute coronary syndrome. Blood levels of cardiac troponin (cTn) may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.
Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.
MORE →Brown v. Board of Education in 1954.