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THE JOURNEY THROUGH TIME

Explore Black History

Explore the people, places, events, achievements, struggles and stories that shaped our journey.

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Civil Rights

Movements, leaders, victories and the continuing fight for equality.

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Innovation, patents, science, technology and world-changing contributions.

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Sports

Pioneers, champions, Negro Leagues, records, activism and excellence.

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People

Meet the people whose lives, choices and achievements shaped the journey.

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Places

Black towns, communities, institutions and places where history happened.

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Events

Moments that changed communities, movements, institutions and the nation.

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MY'STORY

The MOVE Fire

This is a personal recollection on the Move fire on May 13, 1985 Philadelphia police fired thousands of rounds at the MOVE house, city officials approved dropping an explosive device on the roof, the resulting fire was allowed to burn, 11 people—including five children—died, and 61 homes were destroyed. Philadelphia City Council later called it a “brutal attack carried out by the City of Philadelphia on its own citizens” and acknowledged that no individual faced criminal consequences for the bombing. One timeline correction worth preserving for the BHP record: the major previous MOVE-police confrontation was August 8, 1978, about seven years before the bombing, not a year or two earlier. Officer James Ramp was killed, other police and firefighters were wounded, nine MOVE members were later convicted, and television cameras recorded police beating Delbert Africa during his arrest. The 1985 MOVE Commission later specifically criticized city planners for failing to adequately use lessons from that 1978 confrontation. And that actually strengthens the point you’re making: 1985 did not happen without precedent or institutional memory. There had already been a deadly confrontation with MOVE, years of conflict, negotiations and police involvement before Osage Avenue.

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BLACK FACTS
The Truths They Never Taught You...

Ruler of the Mali Empire in the 14th century

Mansa Musa was the ruler of the Mali Empire in West Africa. Details recorded here should be sourced; unknown information is left blank.

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Wikipedia

Troponin C

Cardiac sarcomere structure, featuring troponin C
Troponin

Troponin C (TnC) is part of the troponin protein complex. There are two subtypes in humans:

It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding.

TnC is structurally similar to calmodulin and myosin light chain. These three groups of proteins form a family.[1]

Troponin C, slow skeletal and cardiac muscles
Identifiers
SymbolTNNC1
HGNC11943
OMIM191040
RefSeqNM_003280
UniProtP63316
Other data
LocusChr. 3 p21.1
Search for
StructuresSwiss-model
DomainsInterPro
Troponin C, skeletal muscle
Identifiers
SymbolTNNC2
HGNC11944
OMIM191039
RefSeqNP_003270.1
UniProtP02585
Other data
LocusChr. 20 q13.12
Search for
StructuresSwiss-model
DomainsInterPro

See also

[edit]

References

[edit]
  1. ^ "InterPro: IPR050230 Calmodulin/Myosin light chain/Troponin C-like". www.ebi.ac.uk.
[edit]

Source: Wikipedia. Article content is retrieved live through the MediaWiki API.

Wikipedia

Troponin C

Troponin C (TnC) is part of the troponin protein complex. There are two subtypes in humans: Troponin C, slow skeletal and cardiac muscles (TNNC1) (3p21.1 Online Mendelian Inheritance in Man (OMIM): 191040) Troponin C, skeletal muscle (TNNC2) (20q12-q13.11, Online Mendelian Inheritance in Man (OMIM): 191039) It contains four calcium-binding EF hands, although different isoforms may have fewer than four functional calcium-binding subdomains. It is a component of thin filaments, along with actin and tropomyosin. It contains an N lobe and a C lobe. The C lobe serves a structural purpose and binds to the N domain of troponin I (TnI). The C lobe can bind either Ca2+ or Mg2+. The N lobe, which binds only Ca2+, is the regulatory lobe and binds to the C domain of troponin I after calcium binding. TnC is structurally similar to calmodulin and myosin light chain. These three groups of proteins form a family.

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Wikipedia

Troponin C, slow skeletal and cardiac muscles

Troponin C, slow skeletal and cardiac muscles (TN-C) is a protein encoded in the human by the TNNC1 gene. TN-C resides in the troponin complex on actin thin filaments of striated muscle (slow-twitch cardiac and skeletal) and is responsible for binding calcium to activate muscle contraction. It is one of the two troponin C paralogs in humans.

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Wikipedia

Calmodulin

Calmodulin (CaM) (an abbreviation for calcium-modulated protein) is a multifunctional intermediate calcium-binding messenger protein expressed in all eukaryotic cells. It is an intracellular target of the secondary messenger Ca2+, and the binding of Ca2+ is required for the activation of calmodulin. Once bound to Ca2+, calmodulin acts as part of a calcium signal transduction pathway by modifying its interactions with various target proteins such as kinases or phosphatases.

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Wikipedia

Troponin

Troponin, or the troponin complex, is a complex of three subunits of specialized regulatory proteins –troponin C, troponin I, and troponin T, that are components of the contraction mechanism in striated muscle. Measurements of cardiac-specific troponins I and T are extensively used as diagnostic and prognostic indicators in the management of myocarditis, myocardial infarction and acute coronary syndrome. Blood levels of cardiac troponin (cTn) may be used as a diagnostic marker for stroke or other myocardial injury that is ongoing, although the sensitivity of this measurement is low.

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TOPIC OF THE DAY

Greenwood / Black Wall Street

Before the 1921 destruction of Tulsa’s Greenwood District, Black residents had created a remarkable center of business and community life. The district included stores, professional offices, entertainment venues and homes owned by Black citizens. Understanding Greenwood means learning what was built—not only what was burned.

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TRIVIA QUESTION OF THE DAY

Which Supreme Court case ruled state-sponsored public-school segregation unconstitutional?

Brown v. Board of Education in 1954.